A SEARCH FOR THE FIRST HUMAN
For many of us, the word "genetics" conjures vague thoughts of disease, the human genome, and genetic engineering.
Birth of Adam by Machael Angelo |
Spencer Wells thought "genetics" and forged a unique career that combines his love for history with his passion for biology. A geneticist, adventurer, author, filmmaker, and historian—the man adds new dimension to the term multi-tasking—he is using the cutting-edge of technology to explore human history.
He has traveled the world, collecting blood samples from people of far-flung cultures: Aborigines in Australia, the Chukchi tundra dwellers of Siberia, farmers in the hills of Afghanistan, and nomads in the deserts of Africa. By studying the DNA of modern humans, he seeks to learn who we are, where we traveled to populate the world, and how closely we are all related.
"Each drop of blood is essentially a historical document," Wells said. "Our DNA tells the story of the journey of our species."
New DNA studies suggest that all humans descended from a single African ancestor who lived some 60,000 years ago. To uncover the paths that lead from him to every living human, the National Geographic Society launched the Genographic Project, headed by Spencer Wells. The quest for "Adam" is the subject of a new television documentary that airs on the National Geographic Channel in the U.S. this Sunday.
The project is a five-year endeavor undertaken as a partnership between IBM and National Geographic. It will combine population genetics and molecular biology to trace the migration of humans from the time we first left Africa, 50,000 to 60,000 years ago, to the places where we live today.
Ten research centers around the world have received funding from the Waitt Family Foundation to collect and analyze blood samples from indigenous populations (such as aboriginal groups), many in remote areas. The Genographic Project hopes to collect more than a hundred thousand DNA samples to create the largest gene bank in the world. Members of the public are also being invited to participate.
"Our DNA tells a fascinating story of the human journey: how we are all related and how our ancestors got to where we are today," Wells said. "This project will show us some of the routes early humans followed to populate the globe and paint a picture of the genetic tapestry that connects us all."
Tracing Human History
"As often happens in science," said Wells, "technology has opened up a field to new ways of answering old questions—often providing startling answers."
One of the old questions that intrigued Wells was the question of human origins. Whether early humans evolved in Africa or elsewhere, when they began outward migration, and where they went, are issues that have been argued among archaeologists, anthropologists, and evolutionary biologists for decades.
By analyzing genetic changes in the Y-chromosome of people in all regions of the world, Wells and colleagues concluded that all humans alive today are descended from a single African man.
"We're all effectively cousins, separated by 2,000 generations," he said.
In his book, The Journey of Man: A Genetic Odyssey, Wells describes the exodus from Africa that began around 60,000 years ago, and the path we took to populate the world.
Following the southern coastline of Asia, the first early travelers crossed about 250 kilometers [155 miles] of sea, and colonized Australia by around 50,000 years ago. The Aborigines of Australia, Wells says, are the descendants of the first wave of migration out of Africa.
A second wave left Africa around 45,000 years ago and settled in the Middle East, with smaller groups going off to India, northern China, and southern China. As the glaciers of the Ice Age began to retreat around 40,000 years ago and temperatures warmed up, humans moved into Central Asia and multiplied quickly.
Small groups left Central Asia around 35,000 years ago for Europe. Around 20,000 years ago, another small group of Central Asians moved farther north, into Siberia and the Arctic Circle.
He and his colleagues' paper, published in the September 2003 issue of the American Journal of Human Genetics, added evidence to the debate on the peopling of the Americas. The earliest archaeological evidence of human habitation in North America dates to 11,500 radiocarbon years old. Artifacts at a site in Monte Verde, Chile, are in the 12,500-year-old range. However, there are scientists who believe there is some linguistic and archaeological evidence suggesting the possibility that people may have arrived as much as 30,000 years ago.
Mutations in the Y-chromosome of populations in North and South America put an upper limit on human arrival at somewhere between 18,000 to 15,000 years ago. "I would put the number at closer to 15,000," said Wells.
Legacy of Genghis Khan
In another study that looked at blood samples collected over a period of ten years from more than 40 populations living in and around the former Mongol empire of Genghis Khan, Wells and colleagues found that nearly 8 percent of the men living in the region carry nearly identical Y-chromosomes. That translates to roughly 16 million descendants living today.
Archaeological finds and texts describing the history and culture of the region provide some insight into how this one lineage could be so successful, said Wells.
Khan's empire at the time of his death extended across Asia. His military conquests frequently entailed the wholesale slaughter of the vanquished, wiping out many populations. Contemporary documents report that after a conquest, looting, pillaging, and rape were the spoils of war for all soldiers, but that Khan got first pick of the beautiful women. In addition, his male descendants were markedly prolific. They extended the empire and maintained power in the region for several hundred years, in a culture in which harems and concubines were the norm. Khan's eldest son is reported to have had 40 sons. His grandson, Kublai Khan, had 22 legitimate sons, and was said to add 30 virgins to his harem each year.
"This is a clear example that culture plays a very big role in patterns of genetic variation and diversity in human populations," said Wells.
Lost Empires
In addition to a general passion for history, Wells has an abiding interest in lost empires. One of his current projects involves trying to track down the Phoenicians, a civilization that extended from roughly 3000 B.C. to 332 B.C.
"There's remarkably little archaeological evidence of them, and yet they were the dominant culture of the time," said Wells. "Egyptian texts starting from about 1200 B.C. talk about marauding warriors arriving from the sea, yet we really have no idea who they were or where they came from and where they went."
The Phoenicians were a seafaring people who settled a number of independent city-states around the Mediterranean in modern-day countries Syria, Lebanon, Israel, Tunisia, Greece, and Spain. United by a common language, their alphabet became the prototype for the Greek and Roman alphabets; they were the first people to circumnavigate Africa, and may even have reached America.
But where did they come from and where did they go? For that we'll have to wait for the next installment of Spencer Wells' exploration.
Even if people were not created, but evolved, shouldn’t there be a First Human? Who was this person? And when did he/she appear?
Evolution of Human Race |
Add caption |
Is anything different between this figure and the previous? Not really. Only the terms have been changed. And the important points in our analogy are the following: |
What was previously language, now corresponds to the DNA of an individual; and the ability to communicate between two individuals corresponds to the ability to mate and produce fertile children. |
So, if we take any two individuals from among “our kind”, Homo sapiens, which is the clear red region, no matter how distant in time, these two individuals would be able to produce fertile children after mating (assuming they were a man and a woman), because their DNA’s would be sufficiently similar. The same thing would happen if we took two individuals of our ancestor species, Homo erectus, from the clear magenta region in the figure. Again, the DNA’s of these two individuals, no matter how distant in time, would be sufficiently similar to allow the birth of fertile children. That’s why we say these two belong to the same species, H. erectus, and those two belong to another species, H. sapiens. But if we take one “purple” and one “red” individual, their DNA’s would be different enough to not allow fertile children to be born. It could be that the chances to succeed in having a healthy child would be nearly zero (say, one in a million). Or, that sometimes children would be born, but those children would be unable to have children of their own, so they would be sterile, “dead ends” as far as propagation of genes is concerned.Nonetheless, the magenta region does not change sharply to red, but gradually. There is never any “First Red” individual. If we take any two opposite-sex individuals that belong to succesive generations (but not to the same family obviously, avoiding incest), these two individuals (one from the parent’s generation and the other from the child’s generation) would be able to mate and produce fertile children. They would belong to the “same kind”, even if they were taken from the transitional time of around 200,000 to 150,000 years ago, because their DNA’s would be sufficiently close. How do we know all this? How sure are scientists that the above is true? Have we ever examined the DNA of a H. erectus, and compared it with the DNA of a modern human? No, no one has retrieved DNA from fossil bones as old as those of H. erectus. The oldest DNA that has been retrieved at the time this text was written (ca. 2005) is a few tens of thousand years old. But paleoanthropologist s (scientists who study the origins of the human kind) examine fossils, and are experienced enough to tell with some confidence when a skeleton should belong to one species, and when to another. In reality, we will be nearly 100% certain only when we obtain the DNA of a H. erectus individual, and this will take time, because the older the fossil the more improbable it is that the DNA has been preserved somewhere. But it is not impossible to find it, somewhere on this planet. Perhaps deep frozen under the vast unexplored ice sheets of Siberia (if H. erectus ever reached there). But suppose that we find such a DNA molecule, and after we compare it with a modern DNA molecule we realize — to our surprise — that in fact the two DNA’s are similar enough to qualify as “same species”: the two individual s would in principle be able to have fertile children after mating. Would this discovery demolish the explanation presented in the previous paragraphs, about the nonexistence of a “First Human”? Not at all. Such a discovery would simply push the species-distinction era further back in time. All right, so it would not be what we call H. erectus the species of which we would have the honor to be the descendants. We would be the same species with them, in that case. So? There would be another species, further back in time, that would have sufficiently different DNA to disallow mating and production of offspring with “us”. But still the change between that species and the erectus-sapiens species would be gradual-and-yet-abrupt, as the figure with the magenta and red colors depicts it. And so, still there would be no “First Human”. This notion of “gradual-and-yet-abrupt” change, by the way, is a hard one to grasp, because the words sound self-contradictory: is it gradual, or is it abrupt? But I think the colored figures, above, depict in a nice way how the change can be both gradual and abrupt, without any contradiction:
Naturally, the previous discussion is true for any two species that have an immediate ancestor-descendant relationship; it is not confined to the human ancestry case. |
Though not relevant to the “First Human” question, for the benefit of some readers who objected to the above, I feel I should also mention the following related issues.Some people feel uncomfortable when reading these things. One (unfortunately still common) reaction is: “But does that mean we evolved from the chimpanzees?”
In truth, there is something special between us and chimps. It is that of all living beings on Earth, chimps have a DNA structure which is most similar to ours. This is a hard fact, like “the Earth is round”; it cannot be disputed: you take the chimp-DNA molecule in the lab (an average of some living individuals), and the modern human DNA (again, an average), you compare them, and find some differences. If you do this with any other living being on Earth, you’ll find that the chimp DNA has the fewest differences from our DNA. That’s all that there is to it. And that’s why we look more similar to chimps than to rhinos. And if you continue your DNA-explorations, you’ll find that the next-most-similar DNA to ours after the chimp (the two species of chimps, actually: the common and the bonobo), is the one of the gorilla. And after the gorilla follows the orangutan. And then the gibbon, the “lesser ape”. And then, more distant, are the DNA’s of monkeys and other primates. But still, all these DNA’s are closer to our DNA than, say, the elephant’s DNA. All these are indisputable facts. And the theory of evolution explains these facts. It says, for example, that our common ancestor with the chimps lived more recently than our common ancestor with the gorilla. It is as if we are first cousins with the chimps, but second cousins with the gorillas (and third cousins with the orangutans, and so on). If some readers feel shame that we have such relatives, I would say, I feel more proud of being related to the peaceful bonobo chimps, rather than to some people such as Hitler and Pol Pot. What about you? |
Opinions expressed by readers after reading this pageA reader from a discussion group wrote the following (in their forum, the full text can be found here):
The above reader’s view is wrong on a couple of counts: 1. I don’t attempt to “prove” anything with this analogy. Firstly, real proofs do not exist in any domain other than mathematics. Every use of the word “proof” elsewhere is sloppy. But setting sloppy language aside, and replacing “he proves” (in the first quoted paragraph, above) by “he brings evidence for”, even this idea is wrong: I don’t attempt to bring evidence for anything. An analogy does not bring evidence; it simply invites the mind to remove its blinders and expand its horizon by making a mapping between an unfamiliar idea or situation, and a hopefully more familiar one. An analogy is a thinking aid, not a proving tool. 2. The above reader’s main point is that mine is a “false analogy”, because there is a barrier (I adopt his terminology) between species (e.g., a cat cannot become a dog, and vice versa), whereas there is no such barrier between speakers of languages such as ancient and modern Greek. This idea is wrong for two reasons: 2a. It is not true that speakers can switch between languages such as ancient and modern Greek. I am talking about native speakers.(3) Ancient Greek, as we all know, is a dead language, meaning that there is no native speaker of it alive today. A dead language cannot be revived: we cannot have native speakers of ancient Greek today, no matter which way we try. For to have a native speaker a community of other native speakers is required, and an individual must grow up in that community from a very early age. (There is a “window of opportunity”, well-known in developmental linguistics, available to every mentally normal child, that appears from birth to the early teenage years; a child who is not exposed to a given language during this window of opportunity cannot become a native speaker of that language.) Given that there is no community of speakers speaking ancient Greek, it follows that we cannot have a native speaker of ancient Greek in our times. 2b.Even if the above point (2a) were not true, i.e., even if there were really no barrier between ancient and modern Greek, one must have a sense of which features of an analogy are essential, and which are irrelevant. An analogy is not an isomorphism, forcing every detail to be identical between the two mapped structures. For example, the DNA is propagated by sexual reproduction (at least in the cases of species concerning us here), so a female and a male individual are required; but there is nothing analogous to sexual reproduction in language. On the other hand, a language has a mandatory spoken form and an optional written one, but there is nothing analogous to this in the DNA case. Also, language speakers can be bilinguals or even trilinguals, etc., i.e., native speakers of more than one language, if they grow up in suitable multi-language-speaking environments; but living beings cannot belong to more than one species. All these differences (as well as the purported one suggested by the reader) are irrelevant for the analogy, the essence of which is that just as one does not need to postulate a single initial speaker of a language, so one does not need to postulate a single (or a couple of, male and female) initial ancestor(s) of a species. (Again, this is not a “proof”, or evidence for anything; it is simply a suggestion that it is logically possible to not have a single individual, or couple, as the progenitor of an entire species.) Other opinions, expressed either in public or in private (by email to me) will be answered here, if in my view they raise some interesting point. The privacy of the opinion holder is guaranteed upon request. |
Footnotes (clicking on the number brings back to the text)
1. How do we know this? Because no fossil skeleton or single bone of our kind, Homo sapiens, has been found that is older than around 200,000 years ago.
2. But in case you do happen to be interested in the historical reasons, they are related to Alexander’s conquests. In the centuries after his death, a lot of people in Asia and N. Africa learned to speak Greek. So did the educated among the Romans. Thus, Greek became a “lingua franca”, the international language of those times. However, because it started being spoken not only by native Greeks, but also by “barbarians” (as the Greeks were calling all non-Greeks, but not in the modern derogatory sense), the Greek language was “eroded”. This phenomenon has been repeated many times in history — take, for instance, English and its difference between its modern varieties and the English of Chaucer’s time (1340?-1400). Also, contrary to the modern era, in the ancient times there was no television or radio so as to standardize Greek and let one dialect prevail (e.g., the Attic dialect). Today the so-called “common American” is heard and understood throughout the English-speaking world, thanks to Hollywood and TV series. Back then, however, neither Athens nor any other Greek city had such privileges, so the rest of the Greek speakers eventually brought about the changes that led to the Greek language of the Byzantine times, which are easily understood by modern speakers of Greek.
3. Why the analogy works with native speakers only? Because languages are determined largely by the utterances produced by their native speakers. Non-native speakers can induce changes in a language and cause it to evolve in a catalyst-like fashion, as footnote 2 explains, but they do not determine what the language is. If we include, for example, my ungrammatical Italian as part of the Italian language (because I happen to know a few Italian words and can surmise about how to put them together), and we do this for every non-native speaker of Italian, then the Italian language will lose its character; it will cease to be what it is it will hardly be recognized as Italian.
4. The following thought experiment is possible, however: a number of ancient Greek aficionados gather in a place and form a community. They all know ancient Greek as a second language, i.e., they are not native speakers of it. But they all live in the same locality, marry only with members of their community, and raise their children by speaking to them whatever ancient Greek they know. Modern linguistic theory then predicts that the children raised in this way will become native speakers of ancient Greek (or a close approximation thereof), automatically correcting the non-native errors of their parents. (We have to assume that the parents are very good non-native speakers, otherwise the children might converge to a language that differs substantially from true ancient Greek.) Examples of such a situation come from communities speaking pidgin languages, where children raised within such communities became native speakers of creolized languages.
However still the evolution of Human has unsolved mysteries.
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